2021 MLB All-Star Game Prediction & Odds

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Even though the American League has won each of the last seven Midsummer Classics, it’s the National League that that’s the favorite at sportsbooks to win this year’s All-Star Game. That comes as a bit surprising knowing a number of excellent starting pitchers won’t be making an appearance in the game due to injury or having recently pitched.

Pair that with a loaded AL roster, it looks to me like MLB bettors are getting an absolute bargain if backing the American League at such reduced odds. I think they should be heavier favorites. Hopefully the humidor remains off like it was for the Home Run Derby. Should that be the case, the over might just be a bargain as well regardless of the fact that the under has cashed in at an 11-2-1 clip over the last 14 matchups.

Regardless, the location of the game and roster makeups for both sides should play to a competitive battle once again with each of the last four All-Star Game’s being decided by two or less runs.

The 2021 All-Star Game between the American and National League is scheduled for Tuesday, July 13, 2021, at 7:30 p.m. ET from Coors Field. The matchup will air live on FOX.

When & Where to Watch MLB All-Star Game

The 2021 All-Star Game between the American and National League is scheduled for Tuesday, July 13, 2021, at 7:30 p.m. ET from Coors Field. The matchup will air live on FOX.

2021 MLB All-Star Game Odds

Money Line: American League -103 | National League -107 [BET NOW]

Run Line: American League +1.5 -175 | National League -1.5 +151 [BET NOW]

Total: 10.5 [BET NOW]

Over/Under Analysis

With the game now taking place in the thin air of the Mile High City, linemakers opened the total up in the double-digit range for the first time since 2008 when it was played at Yankee Stadium. That matchup went off the board at 10 yet still played to a comfortable under with the AL besting the NL 4-3.

Coming in at 10.5, this year’s matchup boasts the highest All-Star Game total in recent memory. As for the side, the National League has bounced between -105 and -115 favorites to end its seven-year streak of futility against the American League. You have to go back to the 8-0 shutout in 2012 to find the last time the NL logged its last win over the AL in this exhibition.

All-Star Game Pitchers

National League: Though Jacob deGrom, Brandon Woodruff, Kevin Gausman and Yu Darvish won’t be partaking in the festivities, the NL will still roll with a capable pitching staff mixed with some of the best starting and relief arms the league has to offer. The list includes Corbin Burnes, German Marquez, Trevor Rogers, Zack Wheeler, Craig Kimbrel, Mark Melancon, Josh Hader, Alex Reyes, Walker Buehler, Freddy Peralta, Max Scherzer and Taijuan Walker.

Shohei Ohtani is the first player ever voted into the All-Star Game both as a pitcher and designated hitter.

American League: All eyes will be on Shohei Ohtani with him becoming the first player ever voted into the All-Star Game both as a pitcher and designated hitter. He’ll likely get the starting nod and be followed by the likes of Gerrit Cole, Lance Lynn, Nathan Eovaldi, Kyle Gibson, Yusei Kikuchi, Carlos Rodon, Aroldis Chapman, Liam Hendriks, Matt Barnes, Gregory Soto and Chris Bassitt. The only AL pitcher voted in not playing in the game will be Ryan Pressly while on paternity leave.

Our pick: American League -103

All-Star Game Prediction

Our pick: American League -103

Ohtani’s production both with his arm and bat demands some attention and respect. There hasn’t been another pitcher/hitter in the history of the game that’s been as dominant since Babe Ruth. While he’ll only get a few innings in this one, I still like the AL’s roster much better than that of the NL’s.

Had more of the NL’s top pitchers been made available, I wouldn’t be as confident. Regardless, that AL roster looks to be amazing with it comprised of a good mix of veterans and youngsters. I’m never one to bet against heavy streaks, and the AL’s recent dominance of this exhibition shouldn’t be taken for granted.

If it’s confirmed Coors Field will not use the humidor for the actual game, I’d also recommend betting the over on the total with the bats destined to hold the advantage due to numerous fantastic arms from the National League sitting this one out.

Check out the latest MLB All Star odds.