Buffalo Bills vs Tennessee Titans Predictions & Odds

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The Buffalo Bills made their claim as the best team in the AFC with last week’s 38-20 win in Kansas City in a rematch of the previous season’s conference championship. The Bills go for their fifth straight win when they tangle with another conference powerhouse in the South leading Tennessee Titans in the Week 6 edition of Monday Night Football.

Tennessee handed Buffalo one of its three regular season setbacks with a dominant 42-16 win as a 3-point home dog around this time last year. Buffalo exacted some revenge against KC and will look to do the same against the Titans as a 5.5-point favorite on the NFL betting line.

The Week 6 NFL game between the Buffalo Bills and Tennessee Titans will take place at Nissan Stadium in Nashville, TN at 8:20 p.m. ET on Monday, October 18 and will be televised on ESPN.

The Week 6 NFL game between the Buffalo Bills and Tennessee Titans will take place at Nissan Stadium in Nashville, TN at 8:20 p.m. ET on Monday, October 18 and will be televised on ESPN.

Buffalo Bills vs Tennessee Titans Odds

Buffalo Bills -5.5 | Tennessee Titans +5.5 [BET NOW]

Buffalo Bills vs Tennessee Titans Odds

Buffalo Bills -250 | Tennessee Titans +207 [BET NOW]

Buffalo Bills vs Tennessee Titans Over/Under

Over/Under 54 [BET NOW]

Odds Analysis

Could the Bills be primed for a letdown following their huge win over the Chiefs? I suppose there’s a chance, but Buffalo has emerged as the Super Bowl favorite and earning homefield advantage is a bonus come playoff time. The Bills found that out last season having to travel to KC for the AFC Championship. It’s still only Week 5 and there’s a lot of football remaining, however, the conference is top heavy with eight teams having three wins.

Action on the Bills forced a spike in the line with Buffalo moving to a 5.5-point favorite after hitting the board at -3. The Bills are 4-0 ATS in their last four games. Tennessee has had the easier schedule with its last four games against teams currently below .500. They are 3-1 SU and ATS in those games with a stunning loss to the Jets in overtime the lone setback.

Buffalo Bills

The season-opener against Pittsburgh might have been the best thing to happen to the Bills. Falling at home 23-16 as a 6.5-point favorite made them realize that they can’t just show up and win. They need to actually play with intensity and a purpose. There’s no denying the talent level, but the margin between winning and losing is thin.

Since that loss the Bills have been, dare I say, en fuego. They pitched a couple of shutouts and outscored their last four opponents 156-41. They embarrassed the Chiefs and made Patrick Mahomes look mortal in the process by intercepting two passes, one of which was returned for a touchdown, and forcing four turnovers. The Bills lead the NFL by a lot with 15 takeaways and a plus-11 turnover margin.

Buffalo has a complete outfit topping the NFL in points with 34.4 per game and points against at 12.8. They allow an average of just 78.4 yards on the ground and will be tested by the NFL’s leading rusher Derrick Henry. The Bills just silenced Mahomes to avenge a pair of losses from last season and they’ll look to do the same against Tennessee.

Tennessee Titans

The Titans didn’t let their loss to the previously winless Jets in Week 4 carry over to their game against winless Jacksonville. Henry rushed for 130 yards and Tennessee pulled away for a 37-19 victory, covering the 4-point closing spread. The Titans improved to 3-2 SU and ATS. You could argue that they should have a better record considering the opposition over the last month. The last four opponents all currently have a record below .500 and are a combined 4-16.

We’ll see just how good the Titans are when they take a step up in competition this week. Their only game against a team with a winning record came in the season-opener when the Arizona Cardinals laid a 38-13 beating on them. Tennessee solved the Buffalo riddle in last season’s matchup with a 42-16 thrashing. The Titans were a 3-point home dog in that one and effectively shut down Josh Allen holding him to 263 passing yards and 18 rushing yards while picking off two of his passes.

Defense has been an issue this year. The Jags amassed 454 total yards last week with James Robinson averaging 8.3 yards on 18 rush attempts and Trevor Lawrence throwing for 273 yards. The Titans rank in the bottom third in total defense, pass defense and points allowed. And they’d like to keep the ball out of Allen’s hands as much as possible leaving Henry as a key. If the Titans can run the football behind the league’s leading ground gainer they can control the tempo.

Prediction: Buffalo Bills -5.5 and UNDER 54

Bills vs Titans Prediction

Buffalo’s redemption tour continues. The Bills delivered some payback to the Chiefs last week and they have a chance to do the same in Tennessee. This could be a letdown spot after the emotional week in KC, but the Bills are focused and I don’t think they’ll let that happen.

If anything the Bills have a better play of attack and their defense has been solid making things tough on the home team.

Prediction: Buffalo Bills -5.5 and UNDER 54

View latest NFL Week 6 odds.