College Football Week 10 | Latest Odds and Picks


As the regular season is coming to a close, the teams in contention for their conference crowns and the College Football Playoffs are making for great football. The motivation will be high but only one team can emerge victorious in each matchup.

Here is a look at our picks for Week 10. Latest odds provided by

Arizona Wildcats (-3.5) vs Colorado Buffaloes

The pick: Wildcats -3.5

The University of Arizona pulled off an unlikely upset last time out by throttling Oregon. Running back J.J. Taylor was dominant, carrying the ball 30 times for 212 yards and a pair of touchdowns. Arizona hosts Colorado this week and has clearly found something. The Wildcats are 3.5-point favorites and the choice to cover against a Buffaloes team that is solid but not dominant.


Purdue Boilermakers (-3) vs Iowa Hawkeyes

The pick: Boilermakers -3

The Purdue Boilermakers have been up and down the past few weeks. They picked up a huge home win over Ohio State but then lost last time out on the road to Michigan State. Purdue is back home against the Iowa Hawkeyes this week. The Boilermakers are the choice to cover as 3-point favorites.

Kentucky Wildcats vs Georgia Bulldogs (-9)

The pick: Bulldogs -9

The Kentucky Wildcats have put together a great season, as they won a squeaker last time out to improve to 6-1. They get to host the Georgia Bulldogs in a critical SEC clash on Saturday, but the oddsmakers aren’t giving Kentucky a lot of love. Georgia is the 9-point road favorite, and even at that spread is the right pick. The Bulldogs are going to prove Kentucky is not in their league.

Notre Dame Fighting (-10) Irish vs Northwestern 

The pick: Northwestern +10

The Notre Dame Fighting Irish is a double-digit road favorite against the Northwestern Wildcats. Notre Dame is ranked No. 3 nationally and knows it has a great chance to compete in the College Football Playoff by running the table the rest of the way. Notre Dame should win this game but a 10-point spread on the road is too high. Northwestern is the pick to cover.

Washington Huskies (-9.5) vs Stanford Cardinal

The pick: Huskies -9.5

The Washington Huskies hoped to be a national title contender but have fallen off lately. They lost last time out to California by an ugly score of 12-10 and return home looking for answers. Quarterback Jake Browning was benched against Cal but will return to his starting role against the Stanford Cardinal. Stanford has been struggling too this season. The Huskies are the 9.5-point favorites and are the pick to get back to the right formula with a blowout win. Take Washington to cover in this one.

Clemson Tigers (-38.5) vs Louisville Cardinals

The pick: Cardinals +38.5

One of the largest spreads you will see in a Power 5 matchup features the Clemson Tigers as the 38.5-point favorite against the Louisville Cardinals. Clemson is going to dominate this game but it’s so hard to choose a team that is this big of a favorite against a large-conference foe. The Cardinals are the pick to cover as the second half will be unpredictable once Clemson takes out its starters.

Alabama Crimson Tide (-13.5) vs LSU Tigers

The pick: LSU +13.5

The most anticipated game of Week 10 will be the heavyweight showdown between the Alabama Crimson Tide and the LSU Tigers. Alabama is on the road in this one but is still listed as the heavy 13.5-point favorite.

It’s surprising spread as LSU is ranked No. 4 in the country and has only one loss all season. Despite that, Alabama is the clear best team in the country and the oddsmakers have continued to respect them even against solid foes. While the Crimson Tide is the better team and should pull out this win, the spread is too high. LSU is the best pick of the week to cover as the Tigers are at home and have a talented defense.

Check out the latest college football week 10 betting odds.

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