College Football Week 12 – Moneyline Picks

In college football, the spread gets the majority of the attention, but moneyline plays can be the right call in many instances. The Week 12 slate of action has a lot of intriguing matchups. When a bettor has a good feeling about an underdog, the moneyline can really pay off well as opposed to the lesser odds of the spread.


The moneyline is also a good way to back a favorite because all that matters is the victory, not if the opponent sneaks its way into a backdoor cover. Here are some of the best moneyline plays of Week 12. Odds provided by

Northwestern Wildcats vs Minnesota Gophers

The pick: Wildcats -106

The Northwestern Wildcats continued their storybook run in Big Ten play by knocking off Iowa last time out, which clinched their spot in the conference championship game. Northwestern will aim to head there on a nice winning streak but the oddsmakers aren’t giving much respect, pegging the Wildcats the underdogs on the road against the Minnesota Gophers. Don’t be fooled by the spread. Northwestern at -106 odds is a nice value and the Wildcats should win.

Duke Blue Devils vs Clemson Tigers

The pick: Blue devils +1628

The Duke Blue Devils has had some nice moments this season although the wheels have fallen off a bit lately. They are going on the road as huge underdogs this week against the Clemson Tigers. Duke is obviously a big underdog but it does have a star quarterback. The Blue Devils are worth a small gamble at +1628 odds as they would pay off unbelievably well.

Central Florida Knights vs Cincinnati Bearcats

The pick: Knights -280

The Central Florida Knights are hosting the Cincinnati Bearcats in a critical matchup. UCF is the better team and gets this one at home. The -280 odds are not too steep so roll with the Knights to pick up this victory.

Syracuse Orange vs Notre Dame Fighting Irish

The pick: Orange +278

The Syracuse Orange is going on the road for a matchup against the Notre Dame Fighting Irish. Notre Dame is zeroing in on a College Football Playoff berth but this isn’t an easy matchup. Notre Dame quarterback Ian Book missed the team’s last game due to injury and if there are any issues it could open up a talented Syracuse team to the upset. The odds for the Orange to win this game are set at +278, which is a nice choice.

Cal Bear vs Stanford Cardinal

The pick: Bears +105

The Cal Bears have done a nice job picking up their defense in recent weeks and will host the Stanford Cardinal this week. Stanford has generally won this matchup but Cal is only a slight underdog and has the talent to emerge victorious. Take the Bears at +105 odds.

Arizona State Sun Devils vs Oregon Ducks

The pick: Ducks -175

The Arizona State Sun Devils can win the Pac-12 South with victories in their final two games. The first one up is this week against the Oregon Ducks. Oregon has been very inconsistent recently but gets this one at home. The Ducks should be able to straighten things out and come away with the win at -175 odds.

Michigan State Spartans vs Nebraska Cornhuskers

The pick: Spartans -120

The best moneyline choice of the week comes in a Big Ten showdown. The Michigan State Spartans are hitting the road for a showdown against the Nebraska Cornhuskers. Nebraska has been improved of late but it’s important to remember the team’s entire body of work, which hasn’t been good.

Michigan State has been up and down this season, but the -120 odds are very intriguing. Take the Spartans to win this game. They are the strongest moneyline choice of Week 12 as they get nearly even odds and should come away with a victory over Nebraska.

Check out the latest college football week 12 betting odds.