College Football Week 6 | Moneyline Picks

In sports betting, picking straight up winners can be relatively easy when there’s a large spread between a dominant and weaker team. The oddsmakers know this and will adjust the moneylines accordingly. Of course, the majority of favorites win, but they don’t pay out very well if the line is too high. An underdog upset, meanwhile, can be extremely profitable.


Choosing the right teams on the moneyline is an art. It is less risky than choosing the spread because late touchdowns that are meaningless to the final score can’t result in a backdoor cover. However, a favorite that loses on the moneyline will cause a hit to the bankroll, so bettors have to be careful which teams they choose.

Here is a list at some of the best college football moneyline plays for Week 6.

LSU Tigers (- 145) vs Florida Gators

The pick: LSU Tigers -145

The logic: The LSU Tigers have been one of the most impressive teams in the earlygoing. They have wins already over Miami and Auburn to jump into the top-5 nationally and put themselves squarely in the College Football Playoff conversation. LSU may be able to make the Playoff with one loss but is surely doesn’t want it to come this week. The Tigers must hit the road to face off against the Florida Gators. Florida has been inconsistent on the year but playing at home should give it confident. LSU is the choice as the slight -145 favorite.

Virginia Tech Hokies (+ 211) vs Notre Dame

The pick: Hokies +211

The logic: The Virginia Tech Hokies are hosting the Notre Dame Fighting Irish. Notre Dame has hit a new level with Ian Book being implemented as the starting quarterback, but this is not an easy matchup. The Fighting Irish is the favorite, and the Hokies are the +211 underdogs on the moneyline. It’s possible Notre Dame comes in and takes care of business, but at this price Virginia Tech is a worthy underdog to take on the moneyline.

Arizona State Sun Devils (+125) vs Colorado Buffaloes

The pick: Sun devils +125

The logic: The Arizona State Sun Devils are hitting the road to face off against the Colorado Buffaloes. The talent level on these teams looks pretty even, with the Buffs the favorite in large part because of the home field advantage. The Sun Devils have experience at quarterback and an elite wideout, which makes them a good bet to pull the upset. Arizona State would pay out at +125 with the win on the moneyline.

Texas A&M Aggies (- 220) vs Kentucky Wildcats

The pick: Aggies -220

The logic: The Texas A&M Aggies are welcoming the surprising Kentucky Wildcats to town. Texas A&M is the -220 favorite but that is a much lower number than what was expected when the season began. Don’t be tricked by Kentucky’s hot start. The Aggies are the superior team and are playing at home. Take Texas A&M on the moneyline in this one.

Oklahoma Sooners (- 280) vs Texas Longhorns

The pick: Sooners -280

The logic: The Oklahoma Sooners are matching up against the Texas Longhorns in a neutral site matchup at the Cotton Bowl. Texas’ defense has looked good this year but it faces one of the most electrifying players in the country in Oklahoma quarterback Kyler Murray. His presence alone is good reason to roll with the Sooners at -280 odds on the moneyline.

San Diego State Aztecs (+ 447) vs Boise State Broncos

The pick: Aztecs +447

The logic: One of the most intriguing underdog picks of the week is the San Diego State Aztecs on the road against the Boise State Broncos. There is every reason to believe Boise State will cruise to the win as they have the superior team and are not dealing with as many injuries. However, the Aztecs may be being underestimated in this one. If they can get some unexpected play from some key backups they could make it interesting.

San Diego State could pay out in a huge way as it is a +447 underdog on the moneyline.

Check out the latest college football betting odds for Week 6.

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