Green Bay Packers at San Francisco 49ers Odds & Predictions

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The San Francisco 49ers are somewhat recovered from the rash of injuries that marred last season. With a number of key performers missing a majority of the 2020 campaign the Niners won only six games, one season after posting 13 victories and reaching the Super Bowl.

With those players back the Niners are viewed as a contender and they’re off to a good start with a pair of road wins to open the season. They get a test this week with the Green Bay Packers paying a visit. The Pack rebounded from a Week 1 disaster by lambasting Detroit last week with the offense clicking behind Aaron Rodgers.

The Week 3 matchup between the Green Bay Packers and San Francisco 49ers will take place at Levi’s Stadium at 8:20 p.m. ET on Sunday, September 26 and will be televised on NBC.

The Week 3 matchup between the Green Bay Packers and San Francisco 49ers will take place at Levi’s Stadium at 8:20 p.m. ET on Sunday, September 26 and will be televised on NBC.

Green Bay Packers at San Francisco 49ers Odds

Green Bay Packers +3.5 | San Francisco 49ers -3.5 [BET NOW]

Green Bay Packers at San Francisco 49ers Money Line

Green Bay Packers +151 | San Francisco 49ers -175 [BET NOW]

Green Bay Packers at San Francisco 49ers Over/Under

Over/Under 49.5 [BET NOW]

Odds Analysis

We should see a close game between two teams expected to be in the hunt for the NFC title. Two seasons ago the Niners earned the No. 1 seed finishing tied with Green Bay and New Orleans with 13 victories. The Packers duplicated that win total last year while getting the top-seed. Home field advantage is worth roughly a field goal on the line and wouldn’t you know it the Niners were positioned as a 3.5-point favorite when the spread hit the board.

However, over the last five meetings only one game was decided by fewer than 14 points. Green Bay is 3-2 SU and 2-3 ATS in that stretch. One of those wins came last season against the Niners’ JV team, 34-17, at Levi’s. The total spiked a point to 49.5 with the teams cashing the OVER in the last two games and in nine of the previous 12 encounters.

After leading the NFL in scoring last season with Rodgers winning the MVP, the Pack limped through their opener without scoring a touchdown.

Green Bay Packers

So much for the demise of Rodgers and the Green Bay offense. After leading the NFL in scoring last season with Rodgers winning the MVP, the Pack limped through their opener without scoring a touchdown. Media hacks were all over them after the 35-3 loss with Rodgers tossing two picks and getting replaced by Jordan Love early in the fourth quarter. Rodgers said afterwards that the Packers are in trouble if they start to freak out after one game. So, in typical Rodgers fashion he tossed four scoring passes completing over 82 percent of his passes and the critics were silenced by the 35-17 win.

Okay, let’s temper the hype a little bit. Green Bay beat up a lesser Detroit team at home covering the 11.5-point spread while cashing the OVER. And they’ll get a stiffer test this week from a club with its sights set on returning to the Super Bowl. It took a dominant second half to put the Lions away with the Pack scoring 21 unanswered over the final two quarters. The Packers could have another big offensive showing against a Niners club missing some pieces in the secondary.

Rodgers is obviously the key to the offense but nearly as important is Aaron Jones, who scored four touchdowns and amassed 115 scrimmage yards against the Lions. And an offensive line in transition looked much better on Monday night than it did in the Week 1 loss.

San Francisco 49ers

It’s starting to look like last season all over again, only different players have been shelved with injuries. Starting running back Raheem Mostert was lost for the season in the opener and three other backs were hurt last week. JaMycal Hasty has already been ruled out with Elijah Mitchell and Trey Sermon listed as questionable. For a team that likes to run the football and has enjoyed success doing it, that could be a severe blow.

Though they limited the Eagles to 11 points in last week’s win, the Niners haven’t been devastating on defense. They were outgained by 22 yards in Philly giving up 6.0 yards per play. And they nearly blew a big lead in Detroit in Week 1 with Jared Goff throwing for 338 yards and three touchdowns. Those teams aren’t nearly as good as the Packers with Rodgers at the helm.

The Niners’ secondary is in flux with corners Josh Norman and Emmanuel Moseley listed as questionable. The group is already without Jason Verrett and linebacker Dre Greenlaw. Verrett was lost for the season while Greenlaw was placed on IR. It would be tough enough to stop Rodgers with a full complement of players now the Niners are going at it without a few starters.

Our Prediction: Green Bay Packers +3.5 / OVER 49.5

Packers at 49ers Predictions

Our Prediction: Green Bay Packers +3.5 / OVER 49.5

Now looks like a good time to buy Green Bay. With the exception of the second half last week the Packers haven’t looked good. But this is a club that can turn it on. And with a ravaged 49ers backfield you can expect Jimmy Garoppolo and/or Trey Lance to throw a few more passes. That gives a lot of value to the OVER and I like Green Bay with the half-point hook on the field goal to cover.

View all available NFL Week 3 odds.